Ergothioneine (EGT) essential nutrient? The data says yes!

---

Two 2025 Cell Metabolism studies proved ergothioneine (EGT) activates mitochondrial enzymes that prevent both ferroptosis and glycolytic metabolism. Genetic knockouts completely eliminated all benefits, proving causality. Human data from 20,000+ subjects shows low EGT predicts cognitive decline, cardiovascular disease, and mortality. This mechanism is conserved across humans, dogs, and horses, enabling veterinary diagnostics through Salutarii's Sequential ROS Biomarker Algorithm.

Statistical analysis integrating genetic knockouts, molecular binding studies, performance data, and human epidemiology. Calculates 72-96% probability that EGT depletion causes ferroptosis and Warburg metabolism, with 91% base case estimate. Documents assumptions, limitations, and sensitivity analyses.